To be blunt, you should be concerned that you are using WiFi with a desktop machine...
There is _never_ any good reason for that, & many reasons not to - it can only ever cause problems.
Use Ethernet cables and eliminate the WiFi. If you cannot run a direct cable then get some gigabit Homeplug adapters.
I'd guess you are trying to use an audio interface or DAW software?
Re. DPC latency overall, try to avoid any "software driven" interfaces and use those with built-in hardware buffering and control.
Eliminate all USB except absolutely essential items such an actual audio interface plus the keyboard and mouse - and you could swap those to PS/2 types if the motherboard has PS/2 sockets.
Spread the USB items over different controllers - eg. try the audio interface or any high-throughput item on a USB3 port even if its USB2 & keep other low-throughput items on USB2 ports.
Categorically avoid bluetooth keyboards and mice; basic wireless ones that don't need any special drivers should be OK but cheap bluetooth interfaces are often a major cause of problems.
Even some built-in ethernet devices are software driven, so using a decent "intelligent" ethernet card instead can improve things further.
eg. Something like this: https://www.ebuyer.com/148377-intel-gigabit-pro-1000ct-pcie-desktop-adapter-expi9301ct
Also with audio interfaces, try adjusting the buffer size; there is a "sweet spot" that gives optimum results - too small increases CPU load and is likely to cause jitter, too large increases latency.